Search results for "integrative data analysis"

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Harmonizing behavioral outcomes across studies, raters, and countries: application to the genetic analysis of aggression in the ACTION Consortium

2020

BACKGROUND: Aggression in children has genetic and environmental causes. Studies of aggression can pool existing datasets to include more complex models of social effects. Such analyses require large datasets with harmonized outcome measures. Here, we made use of a reference panel for phenotype data to harmonize multiple aggression measures in school-aged children to jointly analyze data from five large twin cohorts.METHODS: Individual level aggression data on 86,559 children (42,468 twin pairs) were available in five European twin cohorts measured by different instruments. A phenotypic reference panel was collected which enabled a model-based phenotype harmonization approach. A bi-factor i…

MaleNetherlands Twin Register (NTR)InternationalityTwinsInteractionGenetic analysisArticleintegrative data analysis/dk/atira/pure/sustainabledevelopmentgoals/gender_equality03 medical and health sciences0302 clinical medicineTwins DizygoticDevelopmental and Educational Psychologymedicine/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_developmental psychopathologyHumans0501 psychology and cognitive sciencesSiblingChildtwin modelingSDG 5 - Gender EqualityAggressionSiblings05 social sciencesphenotype reference panelTwins MonozygoticSDG 10 - Reduced InequalitiesHeritabilitySocial relationAggressionPsychiatry and Mental healthSocial dynamicsPhenotypePediatrics Perinatology and Child Health/dk/atira/pure/sustainabledevelopmentgoals/reduced_inequalitiesFemalemedicine.symptomPsychology030217 neurology & neurosurgeryDevelopmental psychopathology050104 developmental & child psychologyClinical psychology
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